What are the severe symptoms of aspirin overdose?

What are the severe symptoms of aspirin overdose?

• A. Fever and rash.
• B. Seizures, cerebral edema, pulmonary edema, and metabolic acidosis.
• C. Hypotension with dehydration.
• D. Chronic cough and wheezing.

Answer: (B)

Severe aspirin overdose produces widespread salicylate toxicity that hits the brain and metabolic systems. At high levels, salicylates disrupt cellular energy production, leading to metabolic acidosis, and they stimulate the respiratory center, causing rapid breathing. As toxicity worsens, central nervous system involvement becomes prominent, with seizures and cerebral edema. Pulmonary edema can also occur due to noncardiogenic fluid leakage. This combination of seizures, cerebral edema, pulmonary edema, and metabolic acidosis reflects the life-threatening systemic effects of a significant aspirin overdose. Fever with rash can occur in other contexts, but it does not define the severe overdose pattern, and hypotension or chronic respiratory symptoms are not the hallmark signs.

Severe aspirin overdose produces widespread salicylate toxicity that hits the brain and metabolic systems. At high levels, salicylates disrupt cellular energy production, leading to metabolic acidosis, and they stimulate the respiratory center, causing rapid breathing. As toxicity worsens, central nervous system involvement becomes prominent, with seizures and cerebral edema. Pulmonary edema can also occur due to noncardiogenic fluid leakage. This combination of seizures, cerebral edema, pulmonary edema, and metabolic acidosis reflects the life-threatening systemic effects of a significant aspirin overdose. Fever with rash can occur in other contexts, but it does not define the severe overdose pattern, and hypotension or chronic respiratory symptoms are not the hallmark signs.